CETN2

Across TCGA patient cohorts, CETN2 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CETN2-associated genes across cancer lineages are Caspase-8, EGFR_pY1068, and EGFR. Each is linked with CETN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CETN2-to-partner and partner-to-CETN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by CETN2-low versus CETN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CETN2→partner) and Y-score (partner→CETN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.260	-2.906	.014	.001	3	2
UCEC	EGFR_pY1068 →	-0.300	-3.321	.004	.009	3	1
UCEC	EGFR →	-0.219	-3.295	.001	.009	3	1
UCEC	FASN →	+0.453	+3.169	.006	.018	3	1
UCEC	ACC_pS79 →	+0.372	+3.179	.011	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.203	-3.459	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Caspase-8 by CETN2 expression — UCEC

Explore this box plot interactively →