CETN1

Across TCGA patient cohorts, CETN1 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CETN1-associated genes across cancer lineages are JNK2, p70-S6K_pT389, and PCNA. Each is linked with CETN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CETN1-to-partner and partner-to-CETN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by CETN1-low versus CETN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CETN1→partner) and Y-score (partner→CETN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.246	+2.710	<.001	.003	3	2
UCEC	p70-S6K_pT389 →	-0.203	-3.584	.002	.002	3	2
UCEC	PCNA →	+0.308	+2.874	<.001	<.001	3	2
UCEC	4E-BP1 →	+0.284	+2.700	.002	.005	3	2
UCEC	Cyclin-B1 →	+0.528	+2.584	.007	.010	3	2
COAD	IRS1 →	-0.198	-3.161	.009	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

JNK2 by CETN1 expression — UCEC

Explore this box plot interactively →