CES2

Across TCGA cell cohorts, CES2 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CES2-associated genes across cancer lineages are OR4F6, TRIM49C, and RCVRN. Each is linked with CES2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CES2-to-partner and partner-to-CES2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4F6 grouped by CES2-low versus CES2-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CES2→partner) and Y-score (partner→CES2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OR4F6 →	+0.013	+5.087	<.001	.004	3	1
URINARY_TRACT	TRIM49C →	+0.006	+5.087	<.001	.004	3	1
LUNG_SCLC	RCVRN →	+0.347	+4.044	<.001	.009	3	1
LUNG_SCLC	OPN1MW2 →	+0.477	+4.643	<.001	.004	3	1
LUNG_SCLC	KCNG4 →	+0.710	+4.044	<.001	.009	3	1
LUNG_SCLC	OR6J1 →	+0.030	+4.044	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

OR4F6 by CES2 expression — URINARY_TRACT

Explore this box plot interactively →