CERT1

Across TCGA patient cohorts, CERT1 mutation is significantly associated with the RNA expression of many other genes, with 1,968 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CERT1-associated genes across cancer lineages are RNA5SP44, RNA5SP138, and H2BP8. Each is linked with CERT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CERT1-to-partner and partner-to-CERT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP44 grouped by CERT1-low versus CERT1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CERT1→partner) and Y-score (partner→CERT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNA5SP44 →	+0.266	+3.450	.004	.006	3	2
UCEC	RNA5SP138 →	+0.380	+2.951	<.001	.007	3	2
UCEC	H2BP8 →	+0.060	+3.079	.002	.006	3	2
BLCA	RNU6-799P →	+0.571	+4.558	<.001	.001	3	2
SKCM	LINC00208 →	+0.011	+4.624	<.001	.005	3	2
SKCM	MTND2P16 →	+0.056	+3.451	.004	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,968 associations by consensus.

RNA5SP44 by CERT1 expression — HNSC

Explore this box plot interactively →