CERT1

Across TCGA cell cohorts, CERT1 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible CERT1-associated genes across cancer lineages are KRTAP7-1, DMRTC2, and DYNAP. Each is linked with CERT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CERT1-to-partner and partner-to-CERT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP7-1 grouped by CERT1-low versus CERT1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CERT1→partner) and Y-score (partner→CERT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	KRTAP7-1 →	+0.181	+4.887	<.001	.009	3	1
BLOOD_Lymphoma	DMRTC2 →	+0.013	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	DYNAP →	+0.071	+4.867	.002	.009	3	1
SKIN	KRTAP5-4 →	+0.101	+4.977	<.001	.007	3	1
LARGE_INTESTINE	GJD2 →	+0.004	+4.437	<.001	.004	3	1
LARGE_INTESTINE	SLC15A5 →	+0.016	+5.000	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

KRTAP7-1 by CERT1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →