CERS6

Across TCGA cell cohorts, CERS6 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CERS6-associated genes across cancer lineages are REG3G, IFNL3, and KRTAP4-1. Each is linked with CERS6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CERS6-to-partner and partner-to-CERS6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG3G grouped by CERS6-low versus CERS6-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CERS6→partner) and Y-score (partner→CERS6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	REG3G →	+0.044	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	IFNL3 →	+0.142	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	KRTAP4-1 →	+0.207	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	OR2J2 →	+0.046	+6.247	<.001	<.001	3	1
BLOOD_Lymphoma	KRTAP9-2 →	+0.043	+6.247	<.001	<.001	3	1
BLOOD_Lymphoma	FAM25C →	+0.351	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

REG3G by CERS6 expression — BLOOD_Lymphoma

Explore this box plot interactively →