CERS6

Across TCGA pan-cancer cohorts, CERS6 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated CERS6 data layer compared with 3 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher CERS6 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CERS6 expression acts as an unfavorable survival marker, although some lineages such as KIRC and LUSC show a favorable association.

ACC, UVM, and LIHC are the cancer types where CERS6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.262	0.627	<.001	82	view →
UVM	DFS	Tertile	II,III,IV	0.285	0.806	.001	67	view →
LIHC	DFS	Tertile	All	0.415	0.631	<.001	65	view →
MESO	OS	Quartile	II,III,IV	0.301	0.610	.006	61	view →
HNSC	OS	Median	II,III,IV	0.619	0.803	.001	49	view →
KIRC	DFS	Tertile	All	0.884	0.708	<.001	48	view →
LUSC	OS	Quartile	II,III,IV	0.857	0.621	.001	38	view →
UCEC	DFS	Tertile	All	0.787	0.904	<.001	36	view →
LUAD	OS	Median	All	0.716	0.853	.005	20	view →
KIRP	OS	Quartile	All	0.862	0.966	.002	20	view →
KICH	DFS	Median	II,III,IV	0.575	0.920	.006	16	view →
PAAD	OS	Median	II,III,IV	0.254	0.592	.020	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

CERS6–ACC (DFS)

Open the ACC breakdown →