CERS5

Across TCGA cell cohorts, CERS5 mutation is significantly associated with the mutation status of many other genes, with 1,929 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CERS5-associated genes across cancer lineages are USP34, SMARCA4, and NRG1. Each is linked with CERS5 in more than 2 cancer types. Because this analysis shows association rather than direction, both CERS5-to-partner and partner-to-CERS5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP34 grouped by CERS5-low versus CERS5-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CERS5→partner) and Y-score (partner→CERS5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	USP34 →	+2.779	+4.326	.006	.006	1	3
UPPER_AERODIGESTIVE_TRACT	SMARCA4 →	+5.392	+5.392	.004	.004	1	3
UPPER_AERODIGESTIVE_TRACT	NRG1 →	+5.392	+5.392	.004	.004	1	3
UPPER_AERODIGESTIVE_TRACT	MDM4 →	+5.392	+5.392	.004	.004	1	3
BLOOD_Leukemia	SCARB1 →	+4.309	+4.560	.007	.007	1	3
UPPER_AERODIGESTIVE_TRACT	GRAMD1A →	+5.392	+5.392	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,929 associations by consensus.

USP34 by CERS5 expression — BLOOD_Leukemia

Explore this box plot interactively →