CERS3

Across TCGA patient cohorts, CERS3 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CERS3-associated genes across cancer lineages are p62 Lck ligand, XBP1, and MYH11. Each is linked with CERS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CERS3-to-partner and partner-to-CERS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by CERS3-low versus CERS3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CERS3→partner) and Y-score (partner→CERS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.478	+3.392	<.001	<.001	3	2
UCEC	XBP1 →	-0.157	-1.986	.002	.029	3	2
SKCM	MYH11 →	-0.969	-3.700	.015	.001	3	1
SKCM	YAP_pS127 →	-0.327	-3.169	.049	.018	3	1
SKCM	Caveolin-1 →	-0.753	-2.584	.008	.011	3	1
UCEC	14-3-3_beta →	-0.099	-2.432	.007	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

p62 Lck ligand by CERS3 expression — UCEC

Explore this box plot interactively →