CERS3

Across TCGA pan-cancer cohorts, CERS3 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated CERS3 data layer compared with 3 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher CERS3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CERS3 expression acts as an unfavorable survival marker, although some lineages such as PAAD and LUSC show a favorable association.

COAD, PAAD, and SKCM are the cancer types where CERS3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Quartile	All	0.728	0.853	.004	67	view →
PAAD	OS	Tertile	All	0.605	0.299	<.001	55	view →
SKCM	OS	Quartile	All	0.195	0.438	<.001	44	view →
LUSC	DFS	Quartile	II,III,IV	0.740	0.444	<.001	35	view →
BLCA	OS	Quartile	III,IV	0.551	0.715	.003	29	view →
ACC	OS	Tertile	III,IV	0.451	1.000	.006	18	view →
CESC	DFS	Quartile	All	0.923	0.753	<.001	16	view →
READ	OS	Median	IV	0.878	0.502	.007	16	view →
BRCA	DFS	Tertile	IV	0.335	0.757	.009	14	view →
KIRP	DFS	Median	IV	0.039	0.526	.016	14	view →
LIHC	DFS	Quartile	II,III,IV	0.190	0.410	.011	13	view →
THYM	OS	Median	II,III,IV	0.698	1.000	.012	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

CERS3–COAD (OS)

Open the COAD breakdown →