CERS3

Across TCGA cell cohorts, CERS3 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,275 significant associations in total. CNS shows the largest number of these associations.

The most reproducible CERS3-associated GO terms across cancer lineages are Negative regulation of transcription elongation by RNA polymerase II, miRNA metabolic process, and Regulation of potassium ion transmembrane transport. Each is linked with CERS3 in more than 5 cancer types. Because this analysis shows association rather than direction, both CERS3-to-partner and partner-to-CERS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of transcription elongation by RNA polymerase II grouped by CERS3-low versus CERS3-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CERS3→partner) and Y-score (partner→CERS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Negative regulation of transcription elongation by RNA polymerase II →	+0.072	+0.120	.001	.009	3	5
OESOPHAGUS	miRNA metabolic process →	+0.107	+0.614	.004	.003	2	6
CNS	Regulation of potassium ion transmembrane transport →	-0.081	-0.058	<.001	.001	3	5
CNS	Negative regulation of mRNA metabolic process →	+0.030	+0.082	.001	.002	3	5
SKIN	Peptidyl-cysteine modification →	+0.112	+1.296	<.001	.008	3	4
URINARY_TRACT	Peptidyl-tyrosine autophosphorylation →	+0.189	+0.766	<.001	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,275 associations by consensus.

Negative regulation of transcription elongation by RNA polymerase II by CERS3 expression — BLOOD_Lymphoma

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