CERS3

Across TCGA cell cohorts, CERS3 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CERS3-associated genes across cancer lineages are TDRD15, SLC5A8, and DPPA3. Each is linked with CERS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CERS3-to-partner and partner-to-CERS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TDRD15 grouped by CERS3-low versus CERS3-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CERS3→partner) and Y-score (partner→CERS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TDRD15 →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	SLC5A8 →	+0.070	+4.906	<.001	.006	3	1
SKIN	DPPA3 →	+0.027	+4.273	.002	.006	3	1
LARGE_INTESTINE	TNP1 →	+0.128	+4.415	<.001	.007	3	1
LARGE_INTESTINE	ELOA3DP →	+0.031	+4.273	<.001	.006	3	1
CNS	PRAMEF10 →	+0.276	+4.754	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

TDRD15 by CERS3 expression — OESOPHAGUS

Explore this box plot interactively →