Across TCGA patient cohorts, CERS1 protein abundance is significantly associated with the RNA expression of many other genes, with 2,632 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CERS1-associated genes across cancer lineages are PGAP2, AGBL2, and KCNA2. Each is linked with CERS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CERS1-to-partner and partner-to-CERS1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CERS1→partner) and Y-score (partner→CERS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PGAP2 →	+0.731	+0.945	<.001	.001	3	2
HNSC	AGBL2 →	+0.762	+0.889	.002	.002	3	2
HNSC	KCNA2 →	+1.710	+0.761	.009	.006	3	2
HNSC	MMP1 →	-2.233	-1.043	<.001	.004	3	2
GBM	PRODH →	+1.467	+0.608	<.001	<.001	3	1
GBM	CRYBB3 →	+0.407	+0.410	.006	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,632 associations by consensus.

Exploration

CERS1 survival (RNA) · tumor vs normal (RNA) · all CERS1 data types