Across TCGA patient cohorts, CERS1 mutation is significantly associated with the RNA expression of many other genes, with 1,380 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CERS1-associated genes across cancer lineages are MCM5, GPR143, and SGTA. Each is linked with CERS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CERS1-to-partner and partner-to-CERS1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CERS1→partner) and Y-score (partner→CERS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MCM5 →	+0.618	+2.609	.002	.006	3	2
UCEC	GPR143 →	-0.799	-3.076	.001	<.001	3	2
UCEC	SGTA →	+0.491	+4.191	<.001	<.001	3	2
UCEC	KXD1 →	+0.404	+2.447	.001	.001	3	2
UCEC	KRT23 →	-1.243	-2.393	.004	.003	3	2
UCEC	CAMTA2 →	+0.474	+3.354	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,380 associations by consensus.

Exploration

CERS1 survival (RNA) · tumor vs normal (RNA) · all CERS1 data types