CERNA3

Across TCGA pan-cancer cohorts, CERNA3 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated CERNA3 data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher CERNA3 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated CERNA3 expression acts as an unfavorable survival marker, although some lineages such as UCS and LUAD show a favorable association.

UCS, THYM, and UVM are the cancer types where CERNA3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Median	III,IV	0.530	0.134	<.001	98	view →
THYM	OS	Tertile	II,III,IV	0.615	0.962	.001	62	view →
UVM	DFS	Quartile	II,III,IV	0.391	0.700	.001	62	view →
KICH	DFS	Quartile	All	0.254	0.872	.001	35	view →
LIHC	OS	Quartile	All	0.659	0.856	<.001	35	view →
MESO	DFS	Tertile	All	0.141	0.509	.010	29	view →
KIRP	DFS	Quartile	All	0.766	0.902	.008	29	view →
LUAD	OS	Median	II,III,IV	0.763	0.589	.003	18	view →
UCEC	DFS	Median	All	0.796	0.874	.009	18	view →
GBM	DFS	Quartile	All	0.378	0.177	.007	17	view →
READ	DFS	Median	II,III,IV	0.701	0.862	.016	17	view →
ACC	OS	Tertile	III,IV	0.165	0.525	.021	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

CERNA3–UCS (DFS)

Open the UCS breakdown →