CERNA3

Across TCGA pan-cancer cohorts, CERNA3 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CERNA3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where CERNA3 RNA is repressed in tumor relative to normal tissue. In most cancer types CERNA3 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, LUAD, and LIHC are the cancer types where CERNA3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CERNA3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	All	−0.182	.002	7	view →
LUAD	All	All	+0.179	<.001	6	view →
LIHC	Male	All	+0.177	<.001	6	view →
HNSC	All	All	+0.099	.003	6	view →
BRCA	Female	All	+0.074	.016	6	view →
LUSC	Male	II,III,IV	+0.206	<.001	5	view →
KIRP	All	II,III,IV	+0.131	.006	4	view →
BLCA	All	All	+0.087	.014	4	view →
CHOL	All	All	+0.226	.007	2	view →
ESCA	All	II,III,IV	+0.105	.019	2	view →
STAD	Male	II,III,IV	+0.160	.043	1	view →
THCA	All	All	−0.042	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CERNA3–KICH

Open the KICH breakdown →