CERK

Across TCGA patient cohorts, CERK mutation is significantly associated with the RNA expression of many other genes, with 2,459 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CERK-associated genes across cancer lineages are LINC00709, GPX6, and RNU6-979P. Each is linked with CERK in more than 1 cancer types. Because this analysis shows association rather than direction, both CERK-to-partner and partner-to-CERK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC00709 grouped by CERK-low versus CERK-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CERK→partner) and Y-score (partner→CERK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	LINC00709 →	+0.079	+7.930	<.001	.008	3	2
COAD	GPX6 →	+0.082	+4.020	.005	.002	3	2
COAD	RNU6-979P →	+0.457	+3.868	.007	.003	3	2
COAD	RN7SL83P →	+0.286	+4.070	<.001	.009	3	2
COAD	NXPE2P1 →	+0.382	+5.181	<.001	<.001	3	2
COAD	MIR4799 →	+0.389	+4.399	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,459 associations by consensus.

LINC00709 by CERK expression — LUAD

Explore this box plot interactively →