CERK

Across TCGA pan-cancer cohorts, CERK RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated CERK data layer compared with 3 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CERK RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated CERK expression acts as an unfavorable survival marker, although some lineages such as HNSC and SCLC show a favorable association.

HNSC, ACC, and BLCA are the cancer types where CERK RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	II,III,IV	0.752	0.587	<.001	123	view →
ACC	DFS	Quartile	All	0.246	0.759	<.001	63	view →
BLCA	OS	Tertile	All	0.356	0.556	.001	59	view →
SCLC	DFS	Quartile	II,III,IV	0.735	0.289	<.001	51	view →
OV	OS	Tertile	All	0.255	0.375	.010	48	view →
PAAD	OS	Median	All	0.701	0.517	<.001	45	view →
SARC	OS	Median	All	0.398	0.619	<.001	36	view →
KICH	OS	Quartile	II,III,IV	0.362	1.000	.001	34	view →
LUSC	DFS	Median	III,IV	0.381	0.913	.002	34	view →
BRCA	OS	Tertile	II,III,IV	0.938	0.970	.012	27	view →
KIRP	DFS	Quartile	IV	0.512	0.888	.024	27	view →
KIRC	OS	Quartile	All	0.874	0.756	.004	23	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

CERK–HNSC (DFS)

Open the HNSC breakdown →