CERK

Across TCGA patient cohorts, CERK mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CERK-associated genes across cancer lineages are MEK1, MSH2, and Notch1. Each is linked with CERK in more than 1 cancer types. Because this analysis shows association rather than direction, both CERK-to-partner and partner-to-CERK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by CERK-low versus CERK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CERK→partner) and Y-score (partner→CERK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.344	+2.000	.037	.032	3	2
UCEC	MSH2 →	-0.232	-2.000	.025	.032	3	2
UCEC	Notch1 →	+0.277	+2.700	<.001	.006	3	2
UCEC	Caspase-7-cleavedD198 →	+0.657	+2.479	.014	.010	3	2
UCEC	14-3-3_beta →	-0.112	-2.973	.013	.035	3	1
UCEC	EGFR_pY1068 →	-0.330	-2.000	.003	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

MEK1 by CERK expression — UCEC

Explore this box plot interactively →