CERK

Across TCGA cell cohorts, CERK RNA expression is significantly associated with the go_rna of many other GO terms, with 4,740 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CERK-associated GO terms across cancer lineages are DNA replication-dependent chromatin assembly, Establishment of spindle localization, and Mitotic chromosome condensation. Each is linked with CERK in more than 13 cancer types. Because this analysis shows association rather than direction, both CERK-to-partner and partner-to-CERK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication-dependent chromatin assembly grouped by CERK-low versus CERK-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CERK→partner) and Y-score (partner→CERK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	DNA replication-dependent chromatin assembly →	+0.114	+1.045	<.001	<.001	3	14
SOFT_TISSUE	Establishment of spindle localization →	+0.099	+0.802	<.001	.003	3	12
SOFT_TISSUE	Mitotic chromosome condensation →	+0.152	+1.004	<.001	<.001	3	11
SKIN	Regulation of metaphase plate congression →	+0.160	+1.054	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Meiotic chromosome condensation →	+0.174	+1.034	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Positive regulation of T-helper 17 cell lineage commitment →	+0.161	+0.972	.002	.003	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,740 associations by consensus.

DNA replication-dependent chromatin assembly by CERK expression — SOFT_TISSUE

Explore this box plot interactively →