CERK

Across TCGA cell cohorts, CERK mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CERK-associated genes across cancer lineages are PABPC1L2A, KRTAP12-1, and KRTAP10-5. Each is linked with CERK in more than 1 cancer types. Because this analysis shows association rather than direction, both CERK-to-partner and partner-to-CERK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PABPC1L2A grouped by CERK-low versus CERK-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CERK→partner) and Y-score (partner→CERK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PABPC1L2A →	+0.069	+5.169	<.001	.005	3	1
BREAST	KRTAP12-1 →	+0.104	+5.169	<.001	.005	3	1
BREAST	KRTAP10-5 →	+0.020	+5.781	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR1L3 →	+0.032	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	DPRX →	+0.328	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	NANOGNB →	+0.121	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

PABPC1L2A by CERK expression — BREAST

Explore this box plot interactively →