CERCAM

Across TCGA patient cohorts, CERCAM mutation is significantly associated with the RNA expression of many other genes, with 555 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CERCAM-associated genes across cancer lineages are RNU6-492P, USP9YP10, and MIR4666B. Each is linked with CERCAM in more than 1 cancer types. Because this analysis shows association rather than direction, both CERCAM-to-partner and partner-to-CERCAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-492P grouped by CERCAM-low versus CERCAM-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CERCAM→partner) and Y-score (partner→CERCAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-492P →	+0.478	+7.954	<.001	.008	3	2
LGG	USP9YP10 →	+0.049	+7.977	<.001	.007	3	2
BLCA	MIR4666B →	+0.467	+7.640	<.001	.009	3	2
SKCM	MIR4765 →	+0.126	+4.025	<.001	.007	3	2
READ	RPS14P7 →	+0.187	+5.925	<.001	.002	3	2
SKCM	ASMTL →	+0.492	+3.591	.006	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 555 associations by consensus.

RNU6-492P by CERCAM expression — HNSC

Explore this box plot interactively →