CER1

Across TCGA patient cohorts, CER1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible CER1-associated genes across cancer lineages are CDK1_pY15, HER2, and NDRG1_pT346. Each is linked with CER1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CER1-to-partner and partner-to-CER1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDK1_pY15 grouped by CER1-low versus CER1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CER1→partner) and Y-score (partner→CER1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CDK1_pY15 →	+0.353	+3.014	.022	.018	3	1
SKCM	HER2 →	-0.308	-3.157	.018	.018	2	1
SKCM	NDRG1_pT346 →	-0.779	-3.169	.010	.018	2	1
SKCM	CDK1 →	+0.295	+3.321	<.001	.009	2	1
SKCM	Chk2_pT68 →	+0.219	+3.334	.002	.005	2	1
SKCM	Akt_pT308 →	-0.519	-2.584	.024	.011	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

CDK1_pY15 by CER1 expression — SKCM

Explore this box plot interactively →