CER1

Across TCGA pan-cancer cohorts, CER1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated CER1 data layer compared with 2 for mutation status.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher CER1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CER1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRP show a favorable association.

LIHC, HNSC, and LGG are the cancer types where CER1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Tertile	II,III,IV	0.448	0.724	.001	84	view →
HNSC	DFS	Tertile	IV	0.629	0.170	.001	79	view →
LGG	DFS	Median	All	0.653	0.806	<.001	52	view →
MESO	DFS	Tertile	II,III,IV	0.235	0.435	.016	36	view →
KIRP	OS	Median	All	0.873	0.579	.001	28	view →
ACC	OS	Quartile	All	0.678	0.910	.019	25	view →
UCS	DFS	Tertile	IV	0.932	0.484	.024	24	view →
SCLC	DFS	Median	IV	0.651	0.148	.006	21	view →
LUAD	OS	Tertile	All	0.760	0.628	.034	20	view →
LUSC	OS	Tertile	All	0.889	0.649	.003	17	view →
COAD	DFS	Quartile	II,III,IV	0.233	0.555	.014	14	view →
READ	OS	Quartile	IV	0.468	0.958	.003	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

CER1–LIHC (OS)

Open the LIHC breakdown →