CEP89

Across TCGA patient cohorts, CEP89 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CEP89-associated genes across cancer lineages are ATM, PRDX1, and Rad50. Each is linked with CEP89 in more than 2 cancer types. Because this analysis shows association rather than direction, both CEP89-to-partner and partner-to-CEP89 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by CEP89-low versus CEP89-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEP89→partner) and Y-score (partner→CEP89) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.442	-2.074	<.001	.004	3	3
UCEC	PRDX1 →	+0.126	+1.415	.037	.040	3	2
UCEC	Rad50 →	-0.188	-1.847	.008	.007	3	2
UCEC	eIF4E →	+0.175	+1.637	.004	.001	3	1
UCEC	eIF4G →	+0.273	+3.087	.002	<.001	3	1
UCEC	ERK2 →	+0.147	+1.584	.009	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

ATM by CEP89 expression — UCEC

Explore this box plot interactively →