CEP89

Across TCGA pan-cancer cohorts, CEP89 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of CEP89’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where CEP89 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CEP89 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

KIRP, COAD, and HNSC are the cancer types where CEP89 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CEP89 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	IV	+1.187	<.001	11	view →
COAD	Male	IV	+0.916	<.001	11	view →
HNSC	Male	IV	+0.854	<.001	11	view →
KIRC	Female	All	+0.497	<.001	11	view →
LIHC	Female	II,III,IV	+1.185	<.001	9	view →
THCA	Male	II,III,IV	−0.463	<.001	8	view →
BRCA	All	All	+0.342	<.001	8	view →
KICH	Female	All	−0.975	<.001	7	view →
BLCA	All	All	+0.626	.003	6	view →
LUAD	Male	All	+0.529	.001	6	view →
CHOL	Female	All	+2.670	<.001	5	view →
STAD	All	II,III,IV	+0.598	.002	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

CEP89–KIRP

Open the KIRP breakdown →