CEP89

Across TCGA cell cohorts, CEP89 mutation is significantly associated with the RNA expression of many other genes, with 1,389 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CEP89-associated genes across cancer lineages are OR1N2, GLP1R, and HTR3B. Each is linked with CEP89 in more than 1 cancer types. Because this analysis shows association rather than direction, both CEP89-to-partner and partner-to-CEP89 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1N2 grouped by CEP89-low versus CEP89-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEP89→partner) and Y-score (partner→CEP89) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR1N2 →	+0.024	+3.705	<.001	.007	3	2
SOFT_TISSUE	GLP1R →	+0.027	+4.222	<.001	.007	3	1
SOFT_TISSUE	HTR3B →	+0.257	+4.222	<.001	.007	3	1
SOFT_TISSUE	LALBA →	+1.528	+4.882	<.001	.001	3	1
SOFT_TISSUE	SOX14 →	+0.929	+4.882	<.001	.001	3	1
SOFT_TISSUE	CCR8 →	+0.016	+4.369	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,389 associations by consensus.

OR1N2 by CEP89 expression — BLOOD_Leukemia

Explore this box plot interactively →