CEP70

Across TCGA patient cohorts, CEP70 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CEP70-associated genes across cancer lineages are EGFR_pY1068, N-Ras, and ASNS. Each is linked with CEP70 in more than 1 cancer types. Because this analysis shows association rather than direction, both CEP70-to-partner and partner-to-CEP70 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CEP70-low versus CEP70-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEP70→partner) and Y-score (partner→CEP70) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.328	-3.807	<.001	<.001	3	2
UCEC	N-Ras →	-0.124	-1.571	.008	.036	3	2
UCEC	ASNS →	+0.563	+2.000	<.001	.030	3	2
UCEC	ATM →	-0.564	-2.000	.001	.010	3	2
UCEC	C-Raf →	+0.254	+4.247	<.001	<.001	3	2
UCEC	eIF4G →	+0.281	+2.321	.020	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

EGFR_pY1068 by CEP70 expression — UCEC

Explore this box plot interactively →