CEP57L1

Across TCGA cell cohorts, CEP57L1 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible CEP57L1-associated genes across cancer lineages are CA5A, GLRA4, and RBMY1J. Each is linked with CEP57L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CEP57L1-to-partner and partner-to-CEP57L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CA5A grouped by CEP57L1-low versus CEP57L1-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEP57L1→partner) and Y-score (partner→CEP57L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CA5A →	+0.054	+4.017	<.001	.007	3	1
OESOPHAGUS	GLRA4 →	+0.006	+4.017	<.001	.007	3	1
SKIN	RBMY1J →	+0.006	+4.977	<.001	.007	3	1
LUNG_SCLC	IL3 →	+0.055	+5.029	<.001	.006	3	1
LUNG_SCLC	PRAMEF10 →	+1.180	+5.643	<.001	.002	3	1
LUNG_SCLC	PRAMEF17 →	+0.013	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

CA5A by CEP57L1 expression — OESOPHAGUS

Explore this box plot interactively →