CEP55

Across TCGA patient cohorts, CEP55 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CEP55-associated genes across cancer lineages are p62 Lck ligand, Src_pY416, and 4E-BP1. Each is linked with CEP55 in more than 1 cancer types. Because this analysis shows association rather than direction, both CEP55-to-partner and partner-to-CEP55 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by CEP55-low versus CEP55-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEP55→partner) and Y-score (partner→CEP55) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.536	+3.700	<.001	.001	3	2
UCEC	Src_pY416 →	-0.188	-1.986	.046	.010	3	2
UCEC	4E-BP1 →	+0.301	+3.321	.004	.009	3	2
BLCA	GATA3 →	+0.617	+3.000	.036	.036	3	1
UCEC	EGFR_pY1068 →	-0.228	-2.000	.020	.010	3	1
UCEC	IGFBP2 →	-0.576	-1.584	.024	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

p62 Lck ligand by CEP55 expression — UCEC

Explore this box plot interactively →