CEP41

Across TCGA patient cohorts, CEP41 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CEP41-associated genes across cancer lineages are EGFR_pY1068, FoxM1, and FOXO3a_pS318_S321. Each is linked with CEP41 in more than 1 cancer types. Because this analysis shows association rather than direction, both CEP41-to-partner and partner-to-CEP41 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CEP41-low versus CEP41-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEP41→partner) and Y-score (partner→CEP41) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.386	-2.807	<.001	.003	3	1
UCEC	FoxM1 →	+0.275	+2.807	.015	.003	3	1
UCEC	FOXO3a_pS318_S321 →	-0.134	-2.449	.013	.019	3	1
UCEC	GSK-3_pS9 →	-0.538	-2.321	.002	.033	3	1
UCEC	INPP4B →	-0.311	-2.459	.027	.018	3	1
UCEC	JNK2 →	+0.275	+2.115	.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

EGFR_pY1068 by CEP41 expression — UCEC

Explore this box plot interactively →