CEP295

Across TCGA patient cohorts, CEP295 mutation is significantly associated with the RNA expression of many other genes, with 3,701 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CEP295-associated genes across cancer lineages are OR56A7P, FAM230J, and MAD2L1. Each is linked with CEP295 in more than 2 cancer types. Because this analysis shows association rather than direction, both CEP295-to-partner and partner-to-CEP295 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR56A7P grouped by CEP295-low versus CEP295-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEP295→partner) and Y-score (partner→CEP295) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	OR56A7P →	+0.033	+4.847	<.001	.003	3	3
READ	FAM230J →	+0.012	+4.257	<.001	.007	3	3
UCEC	MAD2L1 →	+0.506	+1.584	.001	.002	3	3
BRCA	TRAJ57 →	+0.312	+3.815	.007	.003	3	3
BRCA	H2BP8 →	+0.086	+4.628	<.001	.004	3	3
CESC	MIR4769 →	+0.199	+4.164	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,701 associations by consensus.

OR56A7P by CEP295 expression — LIHC

Explore this box plot interactively →