CEP250

Across TCGA patient cohorts, CEP250 mutation is significantly associated with the total protein of many other genes, with 89 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CEP250-associated genes across cancer lineages are Rad50, 4E-BP1, and ERK2. Each is linked with CEP250 in more than 3 cancer types. Because this analysis shows association rather than direction, both CEP250-to-partner and partner-to-CEP250 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by CEP250-low versus CEP250-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEP250→partner) and Y-score (partner→CEP250) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.213	-2.237	.002	<.001	3	4
UCEC	4E-BP1 →	+0.356	+2.662	<.001	<.001	3	4
STAD	ERK2 →	+0.255	+2.807	.036	.003	3	3
STAD	Ku80 →	+0.286	+2.321	.017	.032	3	3
STAD	c-Kit →	-0.354	-2.115	.004	.017	3	3
UCEC	Cyclin-B1 →	+0.601	+2.662	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 89 associations by consensus.

Rad50 by CEP250 expression — UCEC

Explore this box plot interactively →