CEP250

Across TCGA cell cohorts, CEP250 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,898 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CEP250-associated GO terms across cancer lineages are Regulation of centriole-centriole cohesion, Negative regulation of calcium ion export across plasma membrane, and Microtubule polymerization. Each is linked with CEP250 in more than 19 cancer types. Because this analysis shows association rather than direction, both CEP250-to-partner and partner-to-CEP250 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of centriole-centriole cohesion grouped by CEP250-low versus CEP250-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CEP250→partner) and Y-score (partner→CEP250) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of centriole-centriole cohesion →	+0.247	+2.102	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	Negative regulation of calcium ion export across plasma membrane →	+0.100	+1.369	<.001	<.001	3	18
STOMACH	Microtubule polymerization →	+0.123	+1.718	<.001	<.001	3	17
LARGE_INTESTINE	Centrosome cycle →	+0.084	+1.047	<.001	<.001	3	16
PANCREAS	Viral translational termination-reinitiation →	+0.085	+1.372	.001	.001	3	16
PANCREAS	Negative regulation of cell cycle phase transition →	+0.074	+1.621	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,898 associations by consensus.

Regulation of centriole-centriole cohesion by CEP250 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →