CEP152

Across TCGA patient cohorts, CEP152 mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CEP152-associated genes across cancer lineages are 4E-BP1, p27_pT157, and Caspase-7-cleavedD198. Each is linked with CEP152 in more than 2 cancer types. Because this analysis shows association rather than direction, both CEP152-to-partner and partner-to-CEP152 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by CEP152-low versus CEP152-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEP152→partner) and Y-score (partner→CEP152) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.274	+3.999	<.001	<.001	3	3
COAD	p27_pT157 →	+0.309	+2.178	<.001	.035	3	2
COAD	Caspase-7-cleavedD198 →	+1.466	+3.330	<.001	.005	3	2
COAD	cIAP →	+0.141	+2.229	.018	.032	2	3
UCEC	eIF4E →	+0.174	+3.013	.003	<.001	3	2
UCEC	FASN →	+0.220	+1.157	.045	.014	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

4E-BP1 by CEP152 expression — UCEC

Explore this box plot interactively →