CEP152

Across TCGA cell cohorts, CEP152 mutation is significantly associated with the mutation status of many other genes, with 3,383 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CEP152-associated genes across cancer lineages are SYMPK, ZNF285, and NOTCH3. Each is linked with CEP152 in more than 3 cancer types. Because this analysis shows association rather than direction, both CEP152-to-partner and partner-to-CEP152 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SYMPK grouped by CEP152-low versus CEP152-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEP152→partner) and Y-score (partner→CEP152) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	SYMPK →	+5.392	+5.392	.004	.004	1	4
LUNG_SCLC	ZNF285 →	+4.502	+5.066	.007	.007	1	4
BLOOD_Leukemia	NOTCH3 →	+2.498	+4.044	<.001	<.001	1	4
LARGE_INTESTINE	VAC14 →	+2.321	+2.146	.008	.008	1	4
LARGE_INTESTINE	TSC2 →	+2.196	+4.550	<.001	<.001	1	4
STOMACH	FMN2 →	+4.584	+3.942	.002	.002	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,383 associations by consensus.

SYMPK by CEP152 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →