CEP135

Across TCGA patient cohorts, CEP135 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CEP135-associated genes across cancer lineages are Caspase-7-cleavedD198, TSC1, and C-Raf. Each is linked with CEP135 in more than 2 cancer types. Because this analysis shows association rather than direction, both CEP135-to-partner and partner-to-CEP135 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CEP135-low versus CEP135-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEP135→partner) and Y-score (partner→CEP135) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.417	+1.341	.018	.017	3	3
LUSC	TSC1 →	+0.390	+2.179	.014	.035	3	2
LUSC	C-Raf →	+0.193	+3.367	.001	.004	3	2
UCEC	14-3-3_beta →	-0.092	-2.475	.002	.001	3	2
UCEC	JNK_pT183_Y185 →	-0.132	-1.584	.008	.017	3	2
UCEC	Ku80 →	+0.214	+1.391	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Caspase-7-cleavedD198 by CEP135 expression — UCEC

Explore this box plot interactively →