CEP135

Across TCGA pan-cancer cohorts, CEP135 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of CEP135’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CEP135 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CEP135 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, KICH, and BLCA are the cancer types where CEP135 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CEP135 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+0.932	<.001	12	view →
KICH	Female	All	−1.343	<.001	10	view →
BLCA	All	III,IV	+0.641	<.001	10	view →
LIHC	Female	II,III,IV	+0.530	<.001	8	view →
STAD	Female	All	+1.127	<.001	7	view →
CHOL	Male	All	+1.448	<.001	5	view →
COAD	Male	All	+0.488	.001	5	view →
ESCA	All	All	+0.921	.002	4	view →
BRCA	All	II,III,IV	+0.384	<.001	4	view →
LUSC	All	All	+0.457	<.001	3	view →
THCA	All	All	−0.301	.001	3	view →
LUAD	All	All	+0.232	.017	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

CEP135–HNSC

Open the HNSC breakdown →