CEP131

Across TCGA patient cohorts, CEP131 mutation is significantly associated with the RNA expression of many other genes, with 3,116 significant associations in total. COAD shows the largest number of these associations.

The most reproducible CEP131-associated genes across cancer lineages are FANCC, OIP5, and UBAC1. Each is linked with CEP131 in more than 3 cancer types. Because this analysis shows association rather than direction, both CEP131-to-partner and partner-to-CEP131 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FANCC grouped by CEP131-low versus CEP131-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEP131→partner) and Y-score (partner→CEP131) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FANCC →	+0.323	+3.263	.003	.008	3	4
SKCM	OIP5 →	+0.939	+3.350	<.001	.005	3	3
SKCM	UBAC1 →	+0.639	+3.604	<.001	.001	3	3
SKCM	PRPS1 →	+0.568	+3.233	.001	.008	3	3
SKCM	POLD1 →	+0.540	+3.350	.009	.005	3	3
COAD	CHAF1B →	+0.603	+2.249	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,116 associations by consensus.

FANCC by CEP131 expression — COAD

Explore this box plot interactively →