CENPT

Across TCGA pan-cancer cohorts, CENPT mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CENPT data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CENPT mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CENPT expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

UCEC, LUAD, and LSCC are the cancer types where CENPT mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.709	1.000	.010	12	view →
LUAD	OS	Tertile	II,III,IV	0.535	0.904	.049	2	view →
LSCC	OS	Tertile	All	0.944	0.739	.040	1	view →
HNSC	OS	Quartile	III,IV	1.000	0.520	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CENPT–UCEC (DFS)

Open the UCEC breakdown →