CENPQ

Across TCGA patient cohorts, CENPQ mutation is significantly associated with the RNA expression of many other genes, with 971 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CENPQ-associated genes across cancer lineages are RNU6-954P, TPMTP3, and SNORD82. Each is linked with CENPQ in more than 1 cancer types. Because this analysis shows association rather than direction, both CENPQ-to-partner and partner-to-CENPQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-954P grouped by CENPQ-low versus CENPQ-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CENPQ→partner) and Y-score (partner→CENPQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-954P →	+0.281	+5.081	<.001	.004	3	2
SKCM	TPMTP3 →	+0.041	+4.594	<.001	.008	3	2
LUSC	SNORD82 →	+0.533	+4.447	.001	.006	3	1
LUSC	RNU6-15P →	+0.355	+4.187	.002	.009	3	1
LUSC	RNU6-1100P →	+0.286	+4.706	<.001	.007	3	1
LUSC	MTCO2P5 →	+0.120	+4.625	.005	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 971 associations by consensus.

RNU6-954P by CENPQ expression — LUSC

Explore this box plot interactively →