CENPN

Across TCGA patient cohorts, CENPN mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CENPN-associated genes across cancer lineages are Annexin-1, c-Myc, and Di-Ras3. Each is linked with CENPN in more than 1 cancer types. Because this analysis shows association rather than direction, both CENPN-to-partner and partner-to-CENPN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by CENPN-low versus CENPN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CENPN→partner) and Y-score (partner→CENPN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.826	+3.604	<.001	.001	3	2
UCEC	c-Myc →	-0.211	-1.687	.043	.044	3	2
UCEC	Di-Ras3 →	-0.150	-3.308	.017	.009	3	2
COAD	GAPDH →	+0.799	+2.815	.004	.036	3	1
UCEC	EGFR_pY1068 →	-0.225	-1.700	.034	.044	3	1
UCEC	EGFR →	-0.230	-3.321	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Annexin-1 by CENPN expression — UCEC

Explore this box plot interactively →