CENPN

Across TCGA pan-cancer cohorts, CENPN RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated CENPN data layer compared with 3 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher CENPN RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CENPN expression acts as an unfavorable survival marker, although some lineages such as THYM and OV show a favorable association.

ACC, MESO, and LUAD are the cancer types where CENPN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.357	0.801	<.001	153	view →
MESO	OS	Median	All	0.378	0.711	<.001	129	view →
LUAD	OS	Quartile	All	0.569	0.745	<.001	70	view →
PAAD	OS	Tertile	All	0.256	0.543	.001	58	view →
KIRP	DFS	Median	All	0.858	0.973	<.001	53	view →
LGG	OS	Median	All	0.718	0.904	<.001	52	view →
BRCA	OS	Tertile	II,III,IV	0.882	0.941	.003	38	view →
LIHC	DFS	Tertile	All	0.437	0.616	<.001	33	view →
KICH	DFS	Tertile	II,III,IV	0.540	0.935	.009	26	view →
KIRC	DFS	Median	III,IV	0.683	0.795	.032	16	view →
THYM	OS	Median	II,III,IV	0.931	0.674	.006	16	view →
OV	OS	Median	IV	0.511	0.251	<.001	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

CENPN–ACC (DFS)

Open the ACC breakdown →