CENPN

Across TCGA cell cohorts, CENPN mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CENPN-associated genes across cancer lineages are MSGN1, GP9, and RNF212B. Each is linked with CENPN in more than 1 cancer types. Because this analysis shows association rather than direction, both CENPN-to-partner and partner-to-CENPN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSGN1 grouped by CENPN-low versus CENPN-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CENPN→partner) and Y-score (partner→CENPN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MSGN1 →	+0.100	+3.930	<.001	.003	3	1
LARGE_INTESTINE	GP9 →	+0.073	+4.196	.007	.002	3	1
LARGE_INTESTINE	RNF212B →	+0.146	+3.678	<.001	.009	3	1
CNS	UGT2B11 →	+0.033	+4.643	<.001	.003	3	1
CNS	C2orf83 →	+0.053	+4.169	<.001	.008	3	1
LUNG_NSCLC_LUAD	SERPINA7 →	+0.006	+5.228	.005	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

MSGN1 by CENPN expression — LARGE_INTESTINE

Explore this box plot interactively →