CENPI

Across TCGA pan-cancer cohorts, CENPI mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated CENPI data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CENPI mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CENPI expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

UCEC, HNSC, and LSCC are the cancer types where CENPI mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	All	0.762	1.000	.038	4	view →
HNSC	DFS	Tertile	III,IV	0.855	0.393	.044	1	view →
LSCC	OS	Median	II,III,IV	0.718	1.000	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

CENPI–UCEC (DFS)

Open the UCEC breakdown →