CENPI

Across TCGA pan-cancer cohorts, CENPI RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of CENPI’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CENPI RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CENPI is over-expressed in tumor.

HNSC, BLCA, and LUAD are the cancer types where CENPI tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CENPI RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.895	<.001	12	view →
BLCA	Female	All	+1.796	<.001	12	view →
LUAD	Male	III,IV	+2.196	<.001	11	view →
COAD	Male	All	+1.330	<.001	11	view →
KIRP	All	IV	+1.212	<.001	11	view →
KIRC	Male	IV	+0.770	<.001	11	view →
LIHC	Female	II,III,IV	+1.016	<.001	9	view →
LUSC	Male	II,III,IV	+2.621	<.001	8	view →
STAD	Female	All	+1.682	<.001	8	view →
READ	All	All	+1.320	<.001	7	view →
UCEC	All	II,III,IV	+1.750	<.001	6	view →
BRCA	All	II,III,IV	+1.587	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

CENPI–HNSC

Open the HNSC breakdown →