CENPI

Across TCGA patient cohorts, CENPI mutation is significantly associated with the RNA expression of many other genes, with 3,923 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CENPI-associated genes across cancer lineages are MRPL18, SLC66A2, and NDUFAF4. Each is linked with CENPI in more than 1 cancer types. Because this analysis shows association rather than direction, both CENPI-to-partner and partner-to-CENPI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPL18 grouped by CENPI-low versus CENPI-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CENPI→partner) and Y-score (partner→CENPI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MRPL18 →	+0.426	+3.198	.004	.009	3	2
SKCM	SLC66A2 →	+0.517	+2.604	.002	.006	3	2
SKCM	NDUFAF4 →	+0.463	+2.604	.008	.006	3	2
SKCM	BCL2L12 →	+0.489	+2.591	.002	.006	3	2
SKCM	TPGS2 →	+0.505	+3.360	.001	.005	3	2
SKCM	TXNL4A →	+0.592	+3.341	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,923 associations by consensus.

MRPL18 by CENPI expression — SKCM

Explore this box plot interactively →