CENPI

Across TCGA cell cohorts, CENPI mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CENPI-associated genes across cancer lineages are TRARG1, OR51I2, and KLF18. Each is linked with CENPI in more than 1 cancer types. Because this analysis shows association rather than direction, both CENPI-to-partner and partner-to-CENPI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRARG1 grouped by CENPI-low versus CENPI-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CENPI→partner) and Y-score (partner→CENPI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TRARG1 →	+0.022	+3.345	<.001	.007	3	1
LARGE_INTESTINE	OR51I2 →	+0.241	+3.781	<.001	.003	3	1
LARGE_INTESTINE	KLF18 →	+0.007	+3.345	<.001	.007	3	1
LARGE_INTESTINE	GRM1 →	+0.045	+3.750	<.001	.007	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

TRARG1 by CENPI expression — LARGE_INTESTINE

Explore this box plot interactively →