CENPE

Across TCGA patient cohorts, CENPE mutation is significantly associated with the total protein of many other genes, with 75 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CENPE-associated genes across cancer lineages are Caspase-7-cleavedD198, Shc_pY317, and 4E-BP1. Each is linked with CENPE in more than 3 cancer types. Because this analysis shows association rather than direction, both CENPE-to-partner and partner-to-CENPE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CENPE-low versus CENPE-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CENPE→partner) and Y-score (partner→CENPE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.098	+3.459	<.001	.005	3	4
UCEC	Shc_pY317 →	-0.158	-1.643	<.001	.002	3	3
UCEC	4E-BP1 →	+0.256	+2.087	<.001	.004	3	3
COAD	Cyclin-B1 →	+0.561	+3.338	.006	.004	3	3
UCEC	eEF2 →	+0.260	+1.678	.006	.019	3	3
UCEC	PCNA →	+0.200	+2.115	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 75 associations by consensus.

Caspase-7-cleavedD198 by CENPE expression — COAD

Explore this box plot interactively →