CENPE

Across TCGA pan-cancer cohorts, CENPE RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of CENPE’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CENPE RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CENPE is over-expressed in tumor.

HNSC, BLCA, and KIRP are the cancer types where CENPE tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CENPE RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.693	<.001	12	view →
BLCA	Male	III,IV	+2.417	<.001	11	view →
KIRP	All	III,IV	+1.018	<.001	11	view →
KIRC	Male	IV	+0.995	<.001	11	view →
STAD	Female	All	+2.095	<.001	10	view →
LUAD	Male	III,IV	+2.126	<.001	9	view →
LIHC	Female	II,III,IV	+1.150	<.001	9	view →
LUSC	Male	III,IV	+3.020	<.001	8	view →
UCEC	All	III,IV	+2.163	<.001	8	view →
BRCA	All	II,III,IV	+1.883	<.001	8	view →
COAD	Male	All	+1.086	<.001	8	view →
ESCA	All	All	+2.005	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

CENPE–HNSC

Open the HNSC breakdown →